It's the reason why getting a cargo hold larger than a Python's 100 (or 115) TC is almost a waste. The Anaconda's is so big as to basically never be fully utilized except maybe when doing massive cargo contracts and side trading along the way, but there's no real need to shrink the Anaconda's cargo capacity since that's one of its few charms. The only other one really is the 7 missile pylons, but lots of much smaller OXP ships seem to have at least that many now.
Some missile pylon using equipment (in OXPs) can be recoded as activate-able equipment thanks to v1.75 changes, so at least that may get better.
If there's multiple stations in a system, an Anaconda might (remotely!) get filled up that way. Way I've got my game set up, there's typically only 1 big secondary station near the main station (Sothis, Superhub, or Globe) with possibly a couple special purposes stations elsewhere in-system (Rock Hermits, Pirate Coves, Black Monks, Buoy Repair, Hoopy Casino, Random Hits Spacebar, Free Trade Zone, Commies stations, Dictators factory, etc.) Even still, my Boa 2 (at 175 TC max) often has space capacity. In-system trading only typically consists of small cargo moves to/from stations I run across on my way to the main station, although I often visit the big secondary station near the main station just because it lets me double up on the big money makers. (computers, luxuries ...or furs, liquors/wines.)