Auto-hide menubars, launch bars popping up in full-screen gameplay

[Bogatyr]

I fly with mouse controls, and on my system (10.14.3, Mojave). When in full-screen mode, and when the mouse moves to the upper or lower portions of the screen, the system menu bar pops down, and receives clicks, which usually results in wreaking havoc on the game (and sometimes the system!). Is there any way for the game to prevent these interruptions in full-screen mode?